Globally, sexually transmitted infections trends are on an increase. Sub-Saharan Africa carries a huge burden of sexually transmitted infections with young adults aged between 16 and 24 years being at higher risk than older adults. Sexually transmitted infections are infections that are mainly transmitted from one person to another through penetrative sexual intercourse, and some are preventable and treatable and others are not. Previous studies show that university students in South Africa comprise a sexually active population, and engage in sexual risk behaviour resulting in sexually transmitted infections that are among the main global causes of sicknesses, long-term disability and death, and have serious psychological and medical consequences for many people across the globe. However, there is a dearth of knowledge on sexually transmitted infections. Knowledge on sexually transmitted infections is vital for preventing and reducing the adverse outcomes of students’ reproductive health. Therefore, this study investigated into the knowledge of sexually transmitted infections and their predictors among university students in the KwaZulu-Natal Province.