COVID-19 has been linked to about 25 million fatalities and more than 110 million cases worldwide. Although it appeared at first that HIV infection was not a risk factor for COVID-19 or more severe disease, recent large studies suggest that HIV-positive persons (especially those with low CD4 cell counts or untreated HIV infection) may have a more severe clinical course than HIVnegative people. Furthermore, the COVID-19 pandemic has interrupted HIV prevention and treatment programmes around the world, posing significant obstacles to maintaining crucial services. We looked at the most important aspects of COVID-19 in HIV-positive persons and identified areas where more research is needed. More than 38 million individuals worldwide are infected with HIV, with over 25 million of them living in Sub-Saharan Africa. Although it is estimated that 26 million individuals living with HIV are on antiretroviral medication (ART), the majority of those who are not on ART and those who are immunosuppressed live in Sub-Saharan Africa. There has not yet been a clear geographic overlap between the COVID-19 and HIV pandemics, which is fortunate because evidence suggests that people living with HIV who become infected with SARSCoV-2 have poor clinical outcomes, especially if they are immunosuppressed or not on antiretroviral therapy (ART).